Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor.

@article{Gether1997AgonistsIC,
  title={Agonists induce conformational changes in transmembrane domains III and VI of the beta2 adrenoceptor.},
  author={Ulrik Gether and Shuangjun Lin and Pejman Ghanouni and Juan Antonio Ballesteros and Harel Weinstein and Brian K. Kobilka},
  journal={The EMBO journal},
  year={1997},
  volume={16 22},
  pages={6737-47}
}
Agonist binding to G protein-coupled receptors is believed to promote a conformational change that leads to the formation of the active receptor state. However, the character of this conformational change which provides the important link between agonist binding and G protein coupling is not known. Here we report evidence that agonist binding to the beta2 adrenoceptor induces a conformational change around 125Cys in transmembrane domain (TM) III and around 285Cys in TM VI. A series of mutant… CONTINUE READING
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