Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.

@article{Xu2005AgonistsFT,
  title={Agonists for the peroxisome proliferator-activated receptor-alpha and the retinoid X receptor inhibit inflammatory responses of microglia.},
  author={Jihong Xu and Paul D Storer and Janet A. Chavis and Michael Karl Racke and Paul D. Drew},
  journal={Journal of neuroscience research},
  year={2005},
  volume={81 3},
  pages={403-11}
}
The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS). In the present study we investigated the effects of PPAR-alpha agonists on primary mouse microglia, a cell type implicated in the pathology of MS and… CONTINUE READING