Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.

@article{Lochner2010AgonistsAA,
  title={Agonists and antagonists bind to an A-A interface in the heteromeric 5-HT3AB receptor.},
  author={Martin Lochner and Sarah C. R. Lummis},
  journal={Biophysical journal},
  year={2010},
  volume={98 8},
  pages={1494-502}
}
The 5-HT3 receptor is a member of the Cys-loop family of transmitter receptors. It can function as a homopentamer (5-HT3A-only subunits) or as a heteropentamer. The 5-HT3AB receptor is the best characterized heteropentamer. This receptor differs from a homopentamer in its kinetics, voltage dependence, and single-channel conductance, but its pharmacology is similar. To understand the contribution of the 5-HT3B subunit to the binding site, we created homology models of 5-HT3AB receptors and… CONTINUE READING

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Atomic force microscopy reveals the stoichiometry and subunit arrangement of 5-HT3 receptors

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