Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice.

@article{Allen2010AgonisticBI,
  title={Agonistic behavior in males and females: effects of an estrogen receptor beta agonist in gonadectomized and gonadally intact mice.},
  author={Amy E Clipperton Allen and Cheryl L. Cragg and Alexis J Wood and Donald W. Pfaff and Elena Choleris},
  journal={Psychoneuroendocrinology},
  year={2010},
  volume={35 7},
  pages={1008-22}
}
Affiliative and agonistic social interactions are mediated by gonadal hormones. Research with estrogen receptor alpha (ERalpha) or beta (ERbeta) knockout (KO) mice show that long-term inactivation of ERalpha decreases, while inactivation of ERbeta increases, male aggression. Opposite effects were found in female alphaERKO and betaERKO mice. The role of acute activation of ERalpha or ERbeta in the agonistic responses of adult non-KO mice is unknown. We report here the effects of the ERbeta… CONTINUE READING