Agonistic anti-ICAM-1 antibodies in scleroderma: Activation of endothelial pro-inflammatory cascades

@inproceedings{Wolf2013AgonisticAA,
  title={Agonistic anti-ICAM-1 antibodies in scleroderma: Activation of endothelial pro-inflammatory cascades},
  author={Sabine I. Wolf and Sarah L Howat and David J. Abraham and Jeremy D. Pearson and Charlotte Lawson},
  booktitle={Vascular pharmacology},
  year={2013}
}
BACKGROUND Scleroderma (SSc) is a complex autoimmune disorder that can be characterised by the presence 2of circulating autoantibodies to nuclear, cytoplasmic and cell surface antigens. In particular antibodies directed against endothelial cell antigens (anti-endothelial cell antibodies; AECA) have been detected. ICAM-1 is an adhesion molecule expressed on… CONTINUE READING