Agonistic and antagonistic activities of chemokines.

  title={Agonistic and antagonistic activities of chemokines.},
  author={Pius Loetscher and I Clark-lewis},
  journal={Journal of leukocyte biology},
  volume={69 6},
Since the discovery of interleukin-8, about 50 chemokines have been identified and characterized. Originally, they were considered as inducible mediators of inflammation, but in recent years, several chemokines were identified that are expressed constitutively and function in physiological traffic and homing of leukocyte-lymphocytes in particular. All chemokines act via seven-transmembrane domain, G protein-coupled receptors. Eighteen such receptors have been identified so far. Studies on… CONTINUE READING

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