Agonistic Properties of Cannabidiol at 5-HT1a Receptors

@article{Russo2005AgonisticPO,
  title={Agonistic Properties of Cannabidiol at 5-HT1a Receptors},
  author={E. B. Russo and A. Burnett and B. Hall and K. Parker},
  journal={Neurochemical Research},
  year={2005},
  volume={30},
  pages={1037-1043}
}
  • E. B. Russo, A. Burnett, +1 author K. Parker
  • Published 2005
  • Chemistry, Medicine
  • Neurochemical Research
  • Cannabidiol (CBD) is a major, biologically active, but psycho-inactive component of cannabis. In this cell culture-based report, CBD is shown to displace the agonist, [3H]8-OH-DPAT from the cloned human 5-HT1a receptor in a concentration-dependent manner. In contrast, the major psychoactive component of cannabis, tetrahydrocannabinol (THC) does not displace agonist from the receptor in the same micromolar concentration range. In signal transduction studies, CBD acts as an agonist at the human 5… CONTINUE READING

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