Agonist-stimulated Cl- efflux from human neutrophils. A common phenomenon during neutrophil activation.

@article{Shimizu1993AgoniststimulatedCE,
  title={Agonist-stimulated Cl- efflux from human neutrophils. A common phenomenon during neutrophil activation.},
  author={Yoshiko Shimizu and Rubenia Daniels and M A Elmore and Michael J Finnen and Maxine E. Hill and J. M. Lackie},
  journal={Biochemical pharmacology},
  year={1993},
  volume={45 9},
  pages={1743-51}
}
When human peripheral blood neutrophils were stimulated with various agonists which activate and/or prime neutrophils, we found that Cl- efflux was enhanced with a dramatic (50%) loss of intracellular Cl-. Interestingly, the Cl- efflux was enhanced by both agonists which induce a rapid transient increase in intracellular Ca2+ concentration ([Ca2+]i) [class… CONTINUE READING