Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.

@article{Virk2008AgonistspecificRO,
  title={Agonist-specific regulation of mu-opioid receptor desensitization and recovery from desensitization.},
  author={Michael S. Virk and John Michael Williams},
  journal={Molecular pharmacology},
  year={2008},
  volume={73 4},
  pages={1301-8}
}
Agonist-selective actions of opioids on the desensitization of mu-opioid receptors (MORs) have been well characterized, but few if any studies have examined agonist-dependent recovery from desensitization. The outward potassium current induced by several opioids was studied using whole-cell voltage-clamp recordings in locus ceruleus neurons. A brief application of the irreversible opioid antagonist beta-chlornaltrexamine (beta-CNA) was applied immediately after treatment of slices with… CONTINUE READING