Agonist-specific cross talk between ERKs and p38(mapk) regulates PGI(2) synthesis in endothelium.

@article{Houliston2001AgonistspecificCT,
  title={Agonist-specific cross talk between ERKs and p38(mapk) regulates PGI(2) synthesis in endothelium.},
  author={Rebecca A Houliston and Jeremy D. Pearson and Caroline P. D. Wheeler-Jones},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={281 4},
  pages={C1266-76}
}
We have examined the mechanisms regulating prostacyclin (PGI(2)) synthesis after acute exposure of human umbilical vein endothelial cells (HUVEC) to interleukin-1 alpha (IL-1 alpha). IL-1 alpha evoked an early (30 min) release of PGI(2) and [(3)H]arachidonate that was blocked by the cytosolic phospholipase A(2)alpha (cPLA(2)alpha) inhibitor arachidonyl trifluoromethyl ketone. IL-1 alpha-mediated activation of extracellular signal-regulated kinase 1/2 (ERK1/2; p42/p44(mapk)) coincided temporally… CONTINUE READING
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