Agonist-selective signaling is determined by the receptor location within the membrane domains.

@article{Zheng2008AgonistselectiveSI,
  title={Agonist-selective signaling is determined by the receptor location within the membrane domains.},
  author={Hui Zheng and Ji Feng Chu and Yu Qiu and Horace H. Loh and P C Law},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 27},
  pages={9421-6}
}
The basis for agonist-selective signaling was investigated by using the mu-opioid receptor (MOR) as a model. In the absence of agonist, MOR located within the lipid raft domains, whereas etorphine, but not morphine, induced the translocation of MOR from lipid raft to nonraft domains, similar to the action of methyl-beta-cyclodextrin. The etorphine-induced MOR translocation required the dissociation of the receptor from Galphai2 first and then the binding of beta-arrestin. In contrast, the low… CONTINUE READING

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