Agonist regulation of human beta2-adrenergic receptor mRNA stability occurs via a specific AU-rich element.

Abstract

Prolonged agonist stimulation of beta2-adrenergic receptors results in receptor down-regulation, which is closely associated with a reduction of the corresponding mRNA, an effect mediated in part by changes in mRNA stability. Transfection experiments with human beta2-adrenergic receptor cDNAs bearing or lacking the untranslated regions suggested that the… (More)

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