Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.

  title={Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin.},
  author={Jeremy G. Richman and Ashley E Brady and Qiong Wang and Jenny Hensel and Roger J Colbran and Lee E. Limbird},
  journal={The Journal of biological chemistry},
  volume={276 18},
Previously, we demonstrated that the third intracellular (3i) loop of the heptahelical alpha2A-adrenergic receptor (alpha2A AR) is critical for retention at the basolateral surface of polarized Madin-Darby canine kidney II (MDCKII) cells following their direct targeting to this surface. Findings that the 3i loops of the D2 dopamine receptors interact with spinophilin (Smith, F. D., Oxford, G. S., and Milgram, S. L. (1999) J. Biol. Chem. 274, 19894-19900) and that spinophilin is enriched beneath… CONTINUE READING
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