Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid.

@article{NeuschferRube1999AgonistinducedPB,
  title={Agonist-induced phosphorylation by G protein-coupled receptor kinases of the EP4 receptor carboxyl-terminal domain in an EP3/EP4 prostaglandin E(2) receptor hybrid.},
  author={Frank Neusch{\"a}fer-Rube and Martin Oppermann and Ulrike Moeller and Ulrike B{\"o}er and Gerhard Paul P{\"u}schel},
  journal={Molecular pharmacology},
  year={1999},
  volume={56 2},
  pages={
          419-28
        }
}
Prostaglandin E(2) receptors (EP-Rs) belong to the family of heterotrimeric G protein-coupled ectoreceptors with seven transmembrane domains. They can be subdivided into four subtypes according to their ligand-binding and G protein-coupling specificity: EP1 couple to G(q), EP2 and EP4 to G(s), and EP3 to G(i). The EP4-R, in contrast to the EP3beta-R, shows rapid agonist-induced desensitization. The agonist-induced desensitization depends on the presence of the EP4-R carboxyl-terminal domain… CONTINUE READING

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