Agonist-induced peroxynitrite production from endothelial cells.

  title={Agonist-induced peroxynitrite production from endothelial cells.},
  author={Neil W. Kooy and James A Royall},
  journal={Archives of biochemistry and biophysics},
  volume={310 2},
Nitric oxide reacts with superoxide to form peroxynitrite, a potential mediator of oxidant-induced cellular injury. The endothelium is a primary target of injury in many pathological states, including acute lung injury, sepsis, multiple organ failure syndrome, and atherosclerosis, where enhanced production of nitric oxide and superoxide occurs… CONTINUE READING