Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent.

@article{Xu2008AgonistinducedIO,
  title={Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent.},
  author={A-Jing Xu and Atsuo Kuramasu and Kay Maeda and Kazuki Kinoshita and Shiori Takayanagi and Yasushi Fukushima and Takehiko Watanabe and Teruyuki Yanagisawa and Jun Sukegawa and Kazuhiko Yanai},
  journal={Journal of neurochemistry},
  year={2008},
  volume={107 1},
  pages={208-17}
}
Histamine H2 receptor (H2R) is a member of G protein-coupled receptor family. Agonist stimulation of H2R results in several cellular events including activation of adenylate cyclase and phospholipase C, desensitization of the receptor, activation of extracellular signal-regulated kinases ERK1/2, and receptor endocytosis. In this study, we identified a GTPase dynamin as a binding partner of H2R. Dynamin could associate with H2R both in vitro and in vivo. Functional analyses using dominant… CONTINUE READING