Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

@article{Rapoport1983AgonistinducedER,
  title={Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.},
  author={Robert M. Rapoport and Ferid Murad},
  journal={Circulation research},
  year={1983},
  volume={52 3},
  pages={352-7}
}
The present study investigates the hypothesis that endothelium-dependent relaxation of vascular smooth muscle may be mediated through the formation of cGMP. Relaxation of the rat thoracic aorta to acetylcholine, histamine, and Ca++ ionophore A23187 was associated with increased levels of cGMP in a time- and concentration-dependent manner, whereas cAMP levels were unaltered. Removal of the endothelium prevented relaxation to these agents and prevented the increased levels of cGMP. Removal of the… CONTINUE READING

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Effect of endothelium-dependent vasodilators on relaxation, cyclic GMP levels and protein phosphorylation in rat thoracic aorta (abstr)

  • RM Rapoport, MB Draznin, GA Martinez, F Murad
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1 Excerpt

Role of the intima in cholinergic and purinergic relaxation of isolated canine femoral arteries

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