Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.

@article{Kocan2009AgonistindependentIB,
  title={Agonist-independent interactions between beta-arrestins and mutant vasopressin type II receptors associated with nephrogenic syndrome of inappropriate antidiuresis.},
  author={Martina Kocan and Heng B. See and Nat{\'a}lia G. Sampaio and Karin Ann Eidne and Brian J. Feldman and Kevin Donald George Pfleger},
  journal={Molecular endocrinology},
  year={2009},
  volume={23 4},
  pages={559-71}
}
Nephrogenic syndrome of inappropriate antidiuresis is a recently identified genetic disease first described in two unrelated male infants with severe symptomatic hyponatremia. Despite undetectable arginine vasopressin levels, patients have inappropriately concentrated urine resulting in hyponatremia, hypoosmolality, and natriuresis. It was found that each infant had a different mutation of the vasopressin type II receptor (V2R) at codon 137 where arginine was converted to cysteine or leucine… CONTINUE READING