Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer

@article{Ango2001AgonistindependentAO,
  title={Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer},
  author={F. Ango and L. Prézeau and T. Muller and J. Tu and B. Xiao and P. Worley and J. Pin and J. Bockaert and L. Fagni},
  journal={Nature},
  year={2001},
  volume={411},
  pages={962-965}
}
G-protein-coupled receptors (GPCRs) transduce signals from extracellular transmitters to the inside of the cell by activating G proteins. Mutation and overexpression of these receptors have revealed that they can reach their active state even in the absence of agonist, as a result of a natural shift in the equilibrium between their inactive and active conformations. Such agonist-independent (constitutive) activity has been observed for the glutamate GPCRs (the metabotropic glutamate receptors… Expand
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