Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3).

  title={Agonist-evoked Ca(2+) wave progression requires Ca(2+) and IP(3).},
  author={John G. McCarron and Susan Chalmers and Debbi Macmillan and Marnie L. Olson},
  journal={Journal of cellular physiology},
  volume={224 2},
Smooth muscle responds to IP(3)-generating agonists by producing Ca(2+) waves. Here, the mechanism of wave progression has been investigated in voltage-clamped single smooth muscle cells using localized photolysis of caged IP(3) and the caged Ca(2+) buffer diazo-2. Waves, evoked by the IP(3)-generating agonist carbachol (CCh), initiated as a uniform rise in cytoplasmic Ca(2+) concentration ([Ca(2+)](c)) over a single though substantial length (approximately 30 microm) of the cell. During… CONTINUE READING