Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.

@article{Prasad2001AgonistdependentRO,
  title={Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.},
  author={Sathyamangla V. Naga Prasad and Larry S Barak and Antonio Rapacciuolo and Marc G. Caron and Howard A Rockman},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 22},
  pages={18953-9}
}
Agonist-dependent desensitization of the beta-adrenergic receptor requires translocation and activation of the beta-adrenergic receptor kinase1 by liberated Gbetagamma subunits. Subsequent internalization of agonist-occupied receptors occurs as a result of the binding of beta-arrestin to the phosphorylated receptor followed by interaction with the AP2 adaptor and clathrin proteins. Receptor internalization is known to require D-3 phosphoinositides that are generated by the action of… CONTINUE READING
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