Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.

@article{Zhang2012AgonistdependentPO,
  title={Agonist-dependent potentiation of vanilloid receptor transient receptor potential vanilloid type 1 function by stilbene derivatives.},
  author={Xuan Zhang and Xiao-na Du and Guo-hong Zhang and Zhan-Feng Jia and Xing-juan Chen and Dong-yang Huang and Bo-yi Liu and Hai-lin Zhang},
  journal={Molecular pharmacology},
  year={2012},
  volume={81 5},
  pages={689-700}
}
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Understanding mechanisms for functional modulation of TRPV1 has important implications. One characteristic of TRPV1 is that channel activity induced by either capsaicin or other activators can be sensitized or modulated by factors involving different cell signaling mechanisms. In this study, we describe a novel mechanism for… CONTINUE READING
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