Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.

@article{Zitzer1999AgonistdependentIO,
  title={Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1.},
  author={Heike Zitzer and Diane E. Richter and Hans J{\"u}rgen Kreienkamp},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 26},
  pages={
          18153-6
        }
}
We report here an interaction between the C terminus of the rat somatostatin receptor subtype 2 (SSTR2) and a protein that has recently been identified as cortactin-binding protein 1 (CortBP1). Interaction is mediated by the PDZ (PSD-95/discs large/ZO-1) domain of CortBP1. As shown by in situ hybridization, SSTR2 and cortactin-binding protein are coexpressed in the rat brain. The association between SSTR2 and the PDZ-domain of CortBP1 was verified by overlay assays and by coprecipitation after… CONTINUE READING
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