Agonist antibodies to TNFR molecules that costimulate T and NK cells.

@article{Melero2013AgonistAT,
  title={Agonist antibodies to TNFR molecules that costimulate T and NK cells.},
  author={Ignacio Melero and Daniel Hirschhorn-Cymerman and Aizea Morales-Kastresana and Miguel F Sanmamed and Jedd D. Wolchok},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2013},
  volume={19 5},
  pages={
          1044-53
        }
}
Therapy for cancer can be achieved by artificially stimulating antitumor T and natural killer (NK) lymphocytes with agonist monoclonal antibodies (mAb). T and NK cells express several members of the TNF receptor (TNFR) family specialized in delivering a costimulatory signal on their surface. Engagement of these receptors is typically associated with proliferation, elevated effector functions, resistance to apoptosis, and differentiation into memory cells. These receptors lack any intrinsic… CONTINUE READING

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