Corpus ID: 24545155

Agonist and potentiation actions of n-octanol on gamma-aminobutyric acid type A receptors.

@article{Kurata1999AgonistAP,
  title={Agonist and potentiation actions of n-octanol on gamma-aminobutyric acid type A receptors.},
  author={Yasutaka Kurata and William Marszalec and Jay Z. Yeh and Toshio Narahashi},
  journal={Molecular pharmacology},
  year={1999},
  volume={55 6},
  pages={
          1011-9
        }
}
The n-octanol effects on the gamma-aminobutyric acid type A (GABAA) receptor were studied in human embryonic kidney 293 cells transfected with alpha1, beta2, and gamma2S subunit cDNAs. GABA-evoked currents had an EC50 of 13.3 +/- 1.7 microM and a Hill coefficient (nH) of 1.4 +/- 0.1. n-Octanol was also capable of evoking a small current with an EC50 of 1000 microM and an nH of 2. In addition, n-octanol modulated GABA-induced currents in a concentration-dependent manner. Coapplications of n… Expand
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