Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy

@article{NewmanTancredi1997AgonistAO,
  title={Agonist activity of antimigraine drugs at recombinant human 5-HT1A receptors: potential implications for prophylactic and acute therapy},
  author={Adrian Newman-Tancredi and Caroline Conte and Christine Chaput and Laurence Verri{\`e}le and V. Audinot-Bouchez and Sylvia Lochon and Gilbert Lavielle and Mark J Millan},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={355},
  pages={682-688}
}
The actions of several serotonergic ligands in use or under development for the treatment of migraine headaches were examined at recombinant human 5-HT1A receptors stably expressed in Chinese Hamster Ovary cells. Affinities (Kis) at this site were determined in competition binding experiments with [3H]-8-OH-DPAT ([3H](±)8-hydroxy-N,N-dipropylaminotetralin), whilst agonist efficacy was measured by stimulation of [35S]-GTPγS (guanylyl-5’-[γ[35S]thio]-triphosphate) binding. Of the prophylactic… 

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