Agonist-Stimulated Pathways of Calcium Signaling in Pancreatic Acinar Cells

@inproceedings{Schulz1999AgonistStimulatedPO,
  title={Agonist-Stimulated Pathways of Calcium Signaling in Pancreatic Acinar Cells},
  author={I. Schulz and E. Krause and A. Gonz{\'a}lez and A. G{\"o}bel and L. Sternfeld and A. Schmid},
  booktitle={Biological chemistry},
  year={1999}
}
Abstract In pancreatic acinar cells stimulation of different intracellular pathways leads to different patterns of Ca2+ signaling. Bombesin induces activation of both phosphatidylinositol 4,5-bisphosphate (PIP2)-specific phospholipase C (PLC) and phospholipase D (PLD). The latter leads to generation of diacylglycerol (DAG) in addition to that produced by activation of PIP2-PLC. Strong activation of protein kinase C (PKC) results in inhibition of Ca2+-induced Ca2+ release from Ca2+ pools… Expand
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