Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.

@article{Pradhan2016AgonistSpecificRO,
  title={Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.},
  author={Amynah Aa Pradhan and Julie Perroy and Wendy M Walwyn and Monique Leana Smith and Ana Vicente-Sanchez and Laura Segura and Alia Bana and Brigitte Lina Kieffer and C. John Evans},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2016},
  volume={36 12},
  pages={
          3541-51
        }
}
UNLABELLED Ligand-specific recruitment of arrestins facilitates functional selectivity of G-protein-coupled receptor signaling. Here, we describe agonist-selective recruitment of different arrestin isoforms to the delta opioid receptor in mice. A high-internalizing delta opioid receptor agonist (SNC80) preferentially recruited arrestin 2 and, in arrestin 2 knock-outs (KOs), we observed a significant increase in the potency of SNC80 to inhibit mechanical hyperalgesia and decreased acute… CONTINUE READING
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