Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors

@article{Smith1998AgonistPO,
  title={Agonist Properties of N,N-Dimethyltryptamine at Serotonin 5-HT2A and 5-HT2C Receptors},
  author={R. Smith and H. Canton and R. Barrett and E. sanders-Bush},
  journal={Pharmacology Biochemistry and Behavior},
  year={1998},
  volume={61},
  pages={323-330}
}
Extensive behavioral and biochemical evidence suggests an agonist role at the 5-HT2A receptor, and perhaps the 5-HT2C receptor, in the mechanism of action of hallucinogenic drugs. However the published in vitro pharmacological properties of N,N-dimethyltryptamine (DMT), an hallucinogenic tryptamine analog, are not consistent with this hypothesis. We, therefore, undertook an extensive investigation into the properties of DMT at 5-HT2A and 5-HT2C receptors. In fibroblasts transfected with the 5… Expand
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References

SHOWING 1-10 OF 21 REFERENCES
Pharmacological activity of the isomers of LY53857, potent and selective 5-HT2 receptor antagonists.
  • 41
Human psychopharmacology of N,N-dimethyltryptamine
  • R. Strassman
  • Psychology, Medicine
  • Behavioural Brain Research
  • 1995
  • 107
  • PDF
Neurochemical and behavioral evidence that quipazine-ketanserin discrimination is mediated by serotonin2A receptor.
  • 61
...
1
2
3
...