Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors

@article{Shoemaker2005AgonistDirectedTO,
  title={Agonist-Directed Trafficking of Response by Endocannabinoids Acting at CB2 Receptors},
  author={Jennifer L Shoemaker and Michael B Ruckle and Philip R. Mayeux and Paul L. Prather},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2005},
  volume={315},
  pages={828 - 838}
}
  • Jennifer L Shoemaker, Michael B Ruckle, +1 author Paul L. Prather
  • Published 2005
  • Medicine, Chemistry
  • Journal of Pharmacology and Experimental Therapeutics
  • This study examined the ability of the endocannabinoids 2-arachidonoyl glycerol (2-AG) and noladin ether as well as the synthetic cannabinoid CP-55,940 [(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl) cyclohexanol] to regulate three intracellular effectors via CB2 receptors in transfected Chinese hamster ovary cells. Although the three agonists regulate all effectors with equivalent efficacy, the rank order of potencies differs depending on which effector is… CONTINUE READING

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