Agonist, antagonist, and inverse agonist characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a selective delta-opioid receptor ligand.

@article{Martin2002AgonistAA,
  title={Agonist, antagonist, and inverse agonist characteristics of TIPP (H-Tyr-Tic-Phe-Phe-OH), a selective delta-opioid receptor ligand.},
  author={Nancy A Martin and Michael B Ruckle and Stephanie L VanHoof and Paul L. Prather},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={301 2},
  pages={661-71}
}
Recent evidence indicates that the well established delta-opioid antagonist TIPP (H-Tyr-Tic-Phe-Phe-OH) also displays agonist activity in several cellular models. Therefore, it is possible that TIPP, and structurally related compounds, might represent a novel class of opioid agonists exhibiting unique characteristics. The purpose of this study was to examine the properties of TIPP at selected points of the signal transduction pathway (i.e., receptor binding, G-protein activation, and effector… CONTINUE READING
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