Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress

@article{Dagyte2011AgomelatineRT,
  title={Agomelatine reverses the decrease in hippocampal cell survival induced by chronic mild stress},
  author={Girstaute Dagyte and Ilaria Crescente and Folkert Postema and Laure Seguin and C{\'e}cilia Gabriel and Elisabeth Moca{\"e}r and J. A. den Boer and Jaap M. Koolhaas},
  journal={Behavioural Brain Research},
  year={2011},
  volume={218},
  pages={121-128}
}
The antidepressant agomelatine is a MT(1)/MT(2) receptor agonist and 5-HT(2C) antagonist. Its antidepressant activity is proposed to result from the synergy between these sets of receptors. Agomelatine-induced changes in the brain have been reported under basal conditions. Yet, little is known about its effects in the brain exposed to chronic stress as a risk factor for major depressive disorder. Recently, we described agomelatine-induced changes on neuronal activity and adult neurogenesis in… CONTINUE READING
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