Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms

@inproceedings{Martinotti2016AgomelatineIB,
  title={Agomelatine Increases BDNF Serum Levels in Depressed Patients in Correlation with the Improvement of Depressive Symptoms},
  author={Giovanni Martinotti and Mauro Pettorruso and Domenico De Berardis and Paola Annunziata Varasano and Gabriella Lucidi Pressanti and Valeria De Remigis and Alessandro Valchera and Valerio Ricci and Marco Di Nicola and Luigi Janiri and Giovanni Biggio and Massimo di Giannantonio},
  booktitle={The international journal of neuropsychopharmacology},
  year={2016}
}
BACKGROUND Agomelatine modulates brain-derived neurotrophic factor expression via its interaction with melatonergic and serotonergic receptors and has shown promising results in terms of brain-derived neurotrophic factor increase in animal models. METHODS Twenty-seven patients were started on agomelatine (25mg/d). Venous blood was collected and brain-derived neurotrophic factor serum levels were measured at baseline and after 2 and 8 weeks along with a clinical assessment, including Hamilton… CONTINUE READING
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