Agomelatine, an innovative pharmacological response to unmet needs

@article{LeStrat2008AgomelatineAI,
  title={Agomelatine, an innovative pharmacological response to unmet needs},
  author={Yann Le Strat and Philip Gorwood},
  journal={Journal of Psychopharmacology},
  year={2008},
  volume={22},
  pages={4 - 8}
}
Abstract Most of the available antidepressants, with different pharmacological profiles, such as inhibitors of serotonin reuptake (SSRIs) or norepinephrine reuptake (NRIs) or both (SNRIs), have limitations leading some patients to drop out of treatment. Another direction of research has therefore been undertaken, based initially on the fact that affective disorders are most often characterized by abnormal patterns of circadian rhythms. This consideration has led to the synthesis of agomelatine… 

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