Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity.

@article{Gressens2008AgomelatineAM,
  title={Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity.},
  author={Pierre Gressens and Leslie Schwendimann and Isabelle Husson and Gergely Sarkozy and Elizabeth Mocaer and Joseph Vamecq and Michael Spedding},
  journal={European journal of pharmacology},
  year={2008},
  volume={588 1},
  pages={58-63}
}
Periventricular leukomalacia is a major cause of cerebral palsy. Perinatal white matter lesions associated with cerebral palsy appears to involve glutamate excitotoxicity. When injected intracerebrally into newborn mice, the glutamatergic analog, ibotenate, induces white matter cysts mimicking human periventricular leukomalacia. Intraperitoneal injection of melatonin was previously shown to be neuroprotective in this mouse model. The goal of the present study was to compare in this model the… CONTINUE READING