Agmatine reverses ethanol consumption in rats: Evidences for an interaction with imidazoline receptors

@article{Taksande2019AgmatineRE,
  title={Agmatine reverses ethanol consumption in rats: Evidences for an interaction with imidazoline receptors},
  author={Brijesh Gulabrao Taksande and Shreesha Nambiar and Shardha Patil and Milind Janraoji Umekar and Manish Manohar Aglawe and Nandkishor R Kotagale},
  journal={Pharmacology Biochemistry and Behavior},
  year={2019},
  volume={186}
}
5 Citations
Effects of imidazoline agents in a rat conditioned place preference model of addiction
TLDR
Assessment of the interaction between AG, IDZ, and EFR with an opiate, tramadol, in a conditioned place preference (CPP) paradigm found that AG reversed the TR-induced CPP, while EFR and IDZ only decreased the time spent in theTR-paired compartment, without statistical significance.

References

SHOWING 1-10 OF 66 REFERENCES
Participation of central imidazoline binding sites in antinociceptive effect of ethanol and nicotine in rats
TLDR
Imidazoline binding ligands are project as important therapeutic molecules for central antinociceptive activity as well as may reduce the co‐abuse potential of alcohol and nicotine.
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors
TLDR
Inhibition of EtOH sensitization by Agmatine is mediated through imidazoline receptors and project agmatine and imidrazoline agents in the pharmacotherapy of alcohol addiction.
Agmatine: Biological role and therapeutic potentials in morphine analgesia and dependence
TLDR
The development of agmatinase inhibitors will offer a useful method to increase endogenous agmatine in the brain as a possible therapeutic approach to potentiate morphine analgesia and reduce dependence/ withdrawal.
Chronic ethanol treatment leads to increased ornithine decarboxylase activity: implications for a role of polyamines in ethanol dependence and withdrawal.
TLDR
Perturbed polyamine homeostasis may represent an important molecular component in the initiation of ethanol withdrawal behaviors in the ethanol-dependent rat.
Agmatine blocks ethanol-induced locomotor hyperactivity in male mice.
Roles for the endocannabinoid system in ethanol-motivated behavior
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