Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure.

@article{Lewis2007AgmatineRB,
  title={Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure.},
  author={Ben Lewis and Kristen A. Wellmann and Susan J Barron},
  journal={Pharmacology, biochemistry, and behavior},
  year={2007},
  volume={88 1},
  pages={114-21}
}
This study examined the effects of binge-like ethanol (ETOH) exposure in neonatal rats on a cerebellar-mediated balance task, and the ability of agmatine, an n-methyl-d-aspartate receptor (NMDAR) modulator, to reverse such effects. Five neonatal treatments groups were used, including ETOH (6.0 g/kg/day), AG (20 mg/kg), ETOH plus AG (6.0 g/kg/day and 20 mg/kg), a maltose control, and a non-treated control. Ethanol was administered via oral intubation twice daily for eight days, (AG was… CONTINUE READING

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