Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis.

@article{Zarifkar2010AgmatinePL,
  title={Agmatine prevents LPS-induced spatial memory impairment and hippocampal apoptosis.},
  author={Asadollah Zarifkar and Samira Choopani and Rasoul Ghasemi and Nasser Naghdi and Amir Maghsoudi and Nader Maghsoudi and K. Rastegar and Maryam Moosavi},
  journal={European journal of pharmacology},
  year={2010},
  volume={634 1-3},
  pages={84-8}
}
Neuroinflammation is associated with a number of neurodegenerative diseases. It is known that lipopolysaccharide (LPS) treatment induces neuroinflammation and memory deterioration. Agmatine, the metabolite of arginine by arginine decarboxylase, is suggested to be a neuroprotective agent. The aim of this study was to explore if agmatine can prevent LPS-induced spatial memory impairment and hippocampal apoptosis. Adult male Wistar rats (200-250 g) were trained in water maze for 4 days (3 days in… CONTINUE READING

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