Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.

@article{Li1998AgmatineIT,
  title={Agmatine inhibited tolerance to and dependence on morphine in guinea pig ileum in vitro.},
  author={Jingwei Li and X Li and Gang Pei and Bin Y Qin},
  journal={Zhongguo yao li xue bao = Acta pharmacologica Sinica},
  year={1998},
  volume={19 6},
  pages={564-8}
}
AIM To observe effect of agmatine (Agm) on tolerance to and substance dependence on morphine (Mor) in guinea pig ileum longitudinal muscle (GPILM). METHODS The experiment was performed in electric field stimulation (EFS) test in vitro. RESULTS Mor inhibited twitch contractions of GPILM induced by EFS [IC50 = 140 (107-182) nmol.L-1]. Incubation of GPILM with Mor 270 nmol.L-1 for 8 h evoked a 37-fold increase in IC50 of Mor (tolerance) and a contractile response to naloxone (Nal, substance… CONTINUE READING

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