Agmatine exerts anticonvulsant effect in mice: modulation by α2-adrenoceptors and nitric oxide

@article{Demehri2003AgmatineEA,
  title={Agmatine exerts anticonvulsant effect in mice: modulation by α2-adrenoceptors and nitric oxide},
  author={Shadpour Demehri and Houman Homayoun and Hooman Honar and Kiarash Riazi and Ahmad Reza Dehpour},
  journal={Neuropharmacology},
  year={2003},
  volume={45},
  pages={534-542}
}
Abstract The effect of agmatine, an endogenous polyamine metabolite, on seizure susceptibility was investigated in mice. Acute intraperitoneal administration of agmatine (5, 10, 20, 40 mg/kg) had a significant and dose-dependent inhibitory effect on pentylenetetrazole (PTZ)-induced seizures. The peak of this anticonvulsant effect was 45 min after agmatine administration. We further investigated the possible involvement of the α 2 -adrenoceptors and l -arginine/NO pathway in this effect of… CONTINUE READING
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