Agmatine does not have activity at alpha 2-adrenoceptors which modulate the firing rate of locus coeruleus neurones: an electrophysiological study in rat.

@article{Pineda1996AgmatineDN,
  title={Agmatine does not have activity at alpha 2-adrenoceptors which modulate the firing rate of locus coeruleus neurones: an electrophysiological study in rat.},
  author={Joseba Pineda and Jos{\'e} {\'A}ngel Ruiz-Ortega and Ra{\'u}l Mart{\'i}n-Ruiz and Luisa Ugedo},
  journal={Neuroscience letters},
  year={1996},
  volume={219 2},
  pages={103-6}
}
Agmatine (decarboxylated arginine) has been proposed as an endogenous ligand for non-adrenoceptor, imidazoline binding sites, but also binds to alpha 2-adrenoceptors. The interaction of agmatine with alpha 2-adrenoceptors was evaluated by studying the effect of agmatine on the firing rate of locus coeruleus (LC) neurones using extracellular recordings in anesthetized rats and rat brain slices. In vivo, local application of agmatine into the LC caused a slight and short-lasting increase in cell… CONTINUE READING

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