Agmatine disrupts prepulse inhibition of acoustic startle reflex in rats.

@article{Uzbay2010AgmatineDP,
  title={Agmatine disrupts prepulse inhibition of acoustic startle reflex in rats.},
  author={Tayfun I. Uzbay and H. Hilal Ezercan Kayir and Gokhan Goktalay and Murat Emrah Yildirim},
  journal={Journal of psychopharmacology},
  year={2010},
  volume={24 6},
  pages={
          923-9
        }
}
Agmatine is a guanidine-amine formed by the enzymatic decarboxylation of arginine. Agmatine has been proposed to be a neuromodulator and its downstream derivatives, the polyamines, have been suggested to be responsible for sensory gating deficits seen in schizophrenia. In this study, male Wistar rats underwent treatments with agmatine, vehicle or other agents known to alter sensory gating in an experimental paradigm of prepulse inhibition (PPI) of the acoustic startle response. Apomorphine (1… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 11 CITATIONS

The pharmacological importance of agmatine in the brain

  • Neuroscience & Biobehavioral Reviews
  • 2012
VIEW 18 EXCERPTS
CITES RESULTS, METHODS & BACKGROUND
HIGHLY INFLUENCED

Varenicline disrupts prepulse inhibition only in high-inhibitory rats

  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2014
VIEW 2 EXCERPTS
CITES RESULTS & METHODS

References

Publications referenced by this paper.
SHOWING 1-10 OF 38 REFERENCES

The changing roles and targets for animal models of schizophrenia

  • Biological Psychiatry
  • 2001
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Glutamatergic mechanisms in schizophrenia.

  • Annual review of pharmacology and toxicology
  • 2002
VIEW 1 EXCERPT

Similar Papers

Loading similar papers…