Agmatine attenuates lipopolysaccharide induced anorexia and sickness behavior in rats.


Sickness behavior is characterized by lethargy, reduced appetite, anhedonia and anxiety. It can be induced in experimental animals by bacterial endotoxin, lipopolysaccharide (LPS). We investigated the impact of intracerebroventricular agmatine injections (5-20μg/rat, icv) on sickness behavior induced by LPS (100μg/rat, ip) in rats. Rats challenged with LPS… (More)
DOI: 10.1016/j.pbb.2015.02.013


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