Agmatine attenuates hyperactivity and weight loss associated with activity-based anorexia in female rats.

@article{Taksande2015AgmatineAH,
  title={Agmatine attenuates hyperactivity and weight loss associated with activity-based anorexia in female rats.},
  author={Brijesh Gulabrao Taksande and Chandrabhan Tukaram Chopde and Milind Janraoji Umekar and Nandkishor Ramdas Kotagale},
  journal={Pharmacology, biochemistry, and behavior},
  year={2015},
  volume={132},
  pages={
          136-141
        }
}
Anorexia nervosa is a debilitating eating disorder characterized by hypophagia, body weight loss, amenorrhea and intense fear of weight gain. In present study, the effect of subchronic agmatine treatment on development of activity based anorexia (ABA) in female rats has been investigated. Animals were injected with saline or agmatine (10-40 mg/kg, ip) just before the onset of dark phase and shifted to experimental cage with wheel for ABA test for 10days. A pre-weighed quantity of food pellets… CONTINUE READING