Agmatine ameliorates manifestation of depression-like behavior and hippocampal neuroinflammation in mouse model of Alzheimer’s disease

  title={Agmatine ameliorates manifestation of depression-like behavior and hippocampal neuroinflammation in mouse model of Alzheimer’s disease},
  author={Nandkishor R Kotagale and R. D. Deshmukh and Madhura P. Dixit and Rajshree Fating and Milind Janraoji Umekar and Brijesh Gulabrao Taksande},
  journal={Brain Research Bulletin},
Agmatine as a novel candidate for rapid-onset antidepressant response
Evidence is sought about the mechanisms that may underlie the fast antidepressant-like responses of agmatine in preclinical studies and whether it may be investigated as a useful compound for the management of MDD associated with a pro-inflammatory state.
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Limonene through Attenuation of Neuroinflammation and Nitrite Level Exerts Antidepressant-Like Effect on Mouse Model of Maternal Separation Stress
It is concluded that the antidepressant-like effects of limonene are probably mediated through inhibition of neuroinflammation and attenuation of nitrite levels in the hippocampus.
Effects of imidazoline agents in a rat conditioned place preference model of addiction
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Minocycline prevents the development of depression-like behavior and hippocampal inflammation in a rat model of Alzheimer’s disease
These findings support the idea that there is a significant relationship among AD, depression-related symptoms, and pro-inflammatory cytokines in the brain, and suggest that antidepressant-like impacts of minocycline could be due to its anti-inflammatory properties.
Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice
The results indicate that AβOs have an acute impact on memory, learning and mood in mice, and that fluoxetine treatment prevented both cognitive impairment and depressive-like behavior induced by A βOs.
Involvement of the agmatinergic system in the depressive-like phenotype of the Crtc1 knockout mouse model of depression
Findings implicate Agmat in the depressive-like phenotype of Crtc1−/− mice, refine current understanding of the agmatinergic system in the brain and highlight its putative role in major depression.
Antidepressant drugs for beta amyloid-induced depression: A new standpoint?
Agmatine, by Improving Neuroplasticity Markers and Inducing Nrf2, Prevents Corticosterone-Induced Depressive-Like Behavior in Mice
The present results reinforce the participation of Nrf2 in the antidepressant-like effect produced by agmatine and expand literature data concerning its mechanisms of action.