Agmatine acts as an antagonist of neuronal nicotinic receptors.

  title={Agmatine acts as an antagonist of neuronal nicotinic receptors.},
  author={Ralph H. Loring},
  journal={British journal of pharmacology},
  volume={99 1},
1. Tritiated agmatine has been used by others in ion flux methods to measure nicotinic receptor function in neurones. However, as shown here, agmatine blocks nicotinic receptor function in both the chick retina and the rat superior cervical ganglion at high concentrations. 2. In intact chick retina, agmatine 1 mM decreases dimethylphenylpiperazinium (DMPP)-induced depolarizations measured in the optic nerve by approximately 70%, while having little effect on responses induced by glutamate… CONTINUE READING


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