Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.

@article{Raasch2002AgmatineAE,
  title={Agmatine, an endogenous ligand at imidazoline binding sites, does not antagonize the clonidine-mediated blood pressure reaction.},
  author={Walter Raasch and Ulrich Sch{\"a}fer and Fatimunnisa Qadri and Peter Dominiak},
  journal={British journal of pharmacology},
  year={2002},
  volume={135 3},
  pages={663-72}
}
Since agmatine has been identified as a clonidine displacing substance (CDS), the aim of this study was to investigate whether agmatine can mimic CDS-induced cardiovascular reactions in organ bath experiments, pithed spontaneously hypertensive rats (SHR) and anaesthetized SHR. Intravenously-administered agmatine significantly reduced the blood pressure and heart rate of anaesthetized SHR at doses higher than 1 and 3 mg kg(-1), respectively. These effects are probably mediated via central… CONTINUE READING

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This suggests that agmatine may modulate noradrenaline release in the same way that clonidine does , i.e. via imidazoline binding sites ; this involves a reduction in sympathetic tone which in turn reduces blood pressure and heart rate .
Agmatine , an endogenous ligand at imidazoline binding sites , does not antagonize the clonidine - mediated blood pressure reaction .
Since agmatine has been identified as a clonidine displacing substance ( CDS ) , the aim of this study was to investigate whether agmatine can mimic CDS - induced cardiovascular reactions in organ bath experiments , pithed spontaneously hypertensive rats ( SHR ) and anaesthetized SHR .
Since agmatine has been identified as a clonidine displacing substance ( CDS ) , the aim of this study was to investigate whether agmatine can mimic CDS - induced cardiovascular reactions in organ bath experiments , pithed spontaneously hypertensive rats ( SHR ) and anaesthetized SHR .
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