Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.

@article{Taksande2010AgmatineAE,
  title={Agmatine, an endogenous imidazoline receptor ligand modulates ethanol anxiolysis and withdrawal anxiety in rats.},
  author={Brijesh Gulabrao Taksande and Nandkishor Ramdas Kotagale and Mital R Patel and Gajanan P. Shelkar and Rajesh Ramesh Ugale and Chandrabhan Tukaram Chopde},
  journal={European journal of pharmacology},
  year={2010},
  volume={637 1-3},
  pages={
          89-101
        }
}
Present study investigated the role of agmatine in ethanol-induced anxiolysis and withdrawal anxiety using elevated plus maze (EPM) test in rats. The anxiolytic-like effect of ethanol was potentiated by pretreatment with imidazoline I(1)/I(2) receptor agonist agmatine (10-20 mg/kg, i.p.), imidazoline I(1) receptor agonists, moxonidine (0.25 mg/kg, i.p.) and clonidine (0.015 mg/kg, i.p.), imidazoline I(2) receptor agonist, 2-BFI (5 mg/kg, i.p.) as well as by the drugs known to increase… CONTINUE READING
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