Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells.

@article{Khanal2011AglyconOR,
  title={Aglycon of rhizochalin from the Rhizochalina incrustata induces apoptosis via activation of AMP-activated protein kinase in HT-29 colon cancer cells.},
  author={Prem B. Khanal and Bong Seok Kang and Hyo Jeong Yun and Hae-Guk Cho and Tatyana N Makarieva and Hong Seok Choi},
  journal={Biological & pharmaceutical bulletin},
  year={2011},
  volume={34 10},
  pages={1553-8}
}
Rhizochalin is a two-headed sphingolipid-like compound isolated from the sponge Rhizochalina incrustata. It has been reported that rhizocalin and its derivates have a chemopreventive and chemotherapeutic effect. However, the molecular mechanism of these effects is not understood. Here, we demonstrate that aglycon of rhizochalin (AglRhz) from the Rhizochalina incrustata induces AMP-activated protein kinase (AMPK) phosphorylation, and thereby inhibits mammalian target of rapamycin (mTOR)-p70S6… CONTINUE READING
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