Agitoxin Footprinting the Shaker Potassium Channel Pore

@article{Gross1996AgitoxinFT,
  title={Agitoxin Footprinting the Shaker Potassium Channel Pore},
  author={Adrian Gross and Roderick MacKinnon},
  journal={Neuron},
  year={1996},
  volume={16},
  pages={399-406}
}
In voltage-dependent K+ channels, each of the four identical subunits contributes one pore loop to the central ion selectivity unit at the interface between the subunits. The pore loop is also the target for scorpion venom peptide inhibitors. These inhibitors bind at the pore entryway between the four subunits and can assume any one of four orientations. The orientations become distinguishable only if the binding site symmetry is disrupted. We have used mutagenesis and site-directed chemical… CONTINUE READING

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