Agitoxin Footprinting the Shaker Potassium Channel Pore

  title={Agitoxin Footprinting the Shaker Potassium Channel Pore},
  author={Adrian Gross and Roderick MacKinnon},
In voltage-dependent K+ channels, each of the four identical subunits contributes one pore loop to the central ion selectivity unit at the interface between the subunits. The pore loop is also the target for scorpion venom peptide inhibitors. These inhibitors bind at the pore entryway between the four subunits and can assume any one of four orientations. The orientations become distinguishable only if the binding site symmetry is disrupted. We have used mutagenesis and site-directed chemical… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 22 references

88 , 2046 – 2050

J. M. Pascual, C.-C. Shieh, G. E. Kirsch, A. M. Brown
Acad . Sci . USA • 1995
View 1 Excerpt

A conductance maximum obWorthington , Freehold , NJ ) , purified by cationexchange chromaserved in an inwardrectifier potassium channel

C. Miller
View 1 Excerpt

Electrostatic potential of the Shaker B K 1 channels : a test for the number of inactivating particles acetylcholine binding sites in the nicotinic receptor probed by reacon each channel

D. A. Stauffer, A. Karlin
Biophys . J . • 1994
View 1 Excerpt

Intima - voltage - dependent K 1 channels from Leiurus quinquestriatus var . tions of K 1 channel structure from a complete functional map of hebraeus venom

L. Kolmakova-Partensky, C. Miller
Biochemistry Biochemistry • 1994

Helix signals in proteins

L. ScienceEscobar, M. J. Root, R. MacKinnon

The aromatic binding pore - forming region of a K 1 channel

R. MacKinnon
Science • 1992

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